By Nima Schei, MD- BELResearch
- Brain systems involved in the generation of Theta oscillations
- Classic Theta model and its inadequacies
- Transmitters and receptors responsible for theta oscillations: roles for cholinergic, GABA-A and NMDA receptors
- Contribution of the Dentate Gyrus and CA3 recurrent collateral system to theta generation
- The involvement of GABAergic interneurons in theta activity
- Intrinsic resonant properties of neurons contribute to theta oscillations
- Timing of action potentials within the theta cycle
- Hippocampus plasticity during theta oscillations
- Significance of theta oscillations and future directions
Although this wave is present in all mammalian hippocampal field potentials, its amplitude and phase varies as a function of depth and creates a unique phase versus depth profile. In addition to CA1 pyramidal neurons in the hippocampus, many other limbic and even neocortical nuclei contain theta rhythm and some of these regions (i.e. MSDBB) are believed to play an essential role in the generation of theta rhythm. Also, some other regions within the hippocampus, such as dentate gyrus and CA3 recurrent collateral system contribute to this rhythm.
Despite the fact that the underlying mechanism behind theta rhythmogenesis is yet unresolved, several models have been developed to explain the generation of theta waves and to describe the unique phase versus depth structure of theta oscillations in the hippocampus. One of the notable models is “classic” theta model which is constituted on collaborations of the septal pacemaker (MSDBB) and follower hippocampal neurons: It is assumed that the hippocampal follower neurons (CA1 pyramidal cells) have passive properties and their activation is solely depends on the sum of EPSPs and IPSPs inputs. The septal pacemaker neurons provide GABAergic inhibitory inputs to basket interneurons and cholinergic depolarizing inputs to both interneurons and pyramidal cells. In addition, neurons of entorhinal cortex provide depolarizing inputs to the distal dendritic region of pyramidal cells. These excitatory and inhibitory dipoles induce perisomatic electrical flow. In a population of pyramidal cells, these extracellular flows would accumulate and eventually produce the theta rhythm.
Although this model is consistent with experimental data and is successful in answering some critical questions about theta oscillations, but suffers from a few inadequacies: For example, unlike the assumption that pyramidal neurons have passive properties, many studies have indicated pyramidal neurons- and also many other neurons in MSDBB and entorhinal cortex- have membrane resonance properties. These neurons have a tendency to oscillate in a preferred range of frequency, around the theta frequency in this case. This intrinsic resonance may contribute to the fact that the theta rhythm preserves a certain range of frequency and also it may play role in the coordination of theta oscillations.
In conclusion, extensive theta waves provide harmonious context for the activity of hippocampal neurons and may produce a synergy between the behavioral state of the nervous system and physiological state of individual components.
-  O’Keefe J., Recce M.L. (1993), Phase relationship between hippocampal place units and the EEG theta rhythm, Hippocampus, 3(3): 317-330
-  Buzsaki G. (2002), Theta oscillations in hippocampus, Neuron, 33:1-20
-  Hirase H., Czurko A., Csicsvari J., Buzsaki G. (1999), Firing rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping’, European journal of neuroscience, 11:4373-4380
-  Geisler C., Diba K., Pastalkova E., Mizuseki K., Royer S., Buzsaki G. (2010), Temporal delays among place cells determine the frequency of population theta oscillations in hippocampus, PNAS, 107(17)7957-7962
-  Kamondi A., Acsady L., Wang X., Buzsaki G. (1998), Tetha oscillations in somata and dendrites of hippocampal pyramidal cells in vivo: activity-dependent phase-precession of action potentials, 8:244-261